Drug development, pre-formulation and formulation

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Drug development, pre-formulation and formulation

Many X-ray analysis tools have earned their place in today’s pharmaceutical development laboratories, especially in the areas of pre-formulation and formulation of solids. The non-destructive character of the analyses often allows a multitude of process steps to be performed on the same sample without destroying its original structure.

PANalytical offers a comprehensive array of X-ray diffraction (XRPD) and X-ray fluorescence (XRF) instruments and related modules that are invaluable in areas of interest such as full characterization of API’s, incl. co-crystals, and excipients.

Typical applications include:

  • Polymorph screening
  • Crystallization studies and scale-up
  • Amorphous versus crystalline determination
  • Investigation of amorphous and nano-crystalline compounds
  • Stability studies
  • Compatibility studies
  • API formulation optimization
  • Tablet morphology and macro structure CT visualization
  • Residual catalyst and related impurity recovery/elimination

Non-destructive drug characterization and analysis solutions

PANalytical’s XRPD instrument platforms, Empyrean and X’Pert³ Powder and CubiX³ Pharma provide the highest degree of laboratory experimental flexibility and throughput desired by pharmaceutical research and development programs.

Energy dispersive (ED) XRF spectrometers like Epsilon 4, offer quick and reliable elemental analysis designed to provide rapid answers to confirm development processes such as removal of residual catalysts. Designed for use by non-experts samples can be analyzed with minimal or no sample preparation.

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