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Performance validation of ScatterX78 against NIST reference materials

SAXS for particle size distribution analysis of colloidal gold nanoparticles

SAXS measurements were performed on a set of nanoparticle size reference materials from NIST. The experimental data acquired with ScatterX78 were analyzed with the EasySAXS software to determine the nanoparticle size distributions. All results were found to be precise and accurate, and in good agreement with the values given by NIST. Additional tests on multi-modal particle size distributions demonstrated the power of the indirect Fourier transformation approach for data analysis.

The set of NIST reference materials RM 8011, 8012 and 8013 consist of highly dilute (0.005 wt.%) aqueous dispersions of gold nanoparticles with nominal particle sizes of 10, 30 and 60 nm, respectively. Generally these are intended for the evaluation and qualification of methodology and/or instrument performance related to the physical/dimensional characterization of nanoscale particles used in pre-clinical biomedical research. The reference materials were used to validate experimental SAXS data acquired with ScatterX78 and analyzed with the EasySAXS analysis software.

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