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Application note

High-resolution, high-throughput XRPD

Cimetidine polymorph screening

An important step in drug development is the investigation of polymorphs, chemically identical substances present in different crystallographic forms. Active pharmaceutical ingredients often occur in various polymorphic forms, potentially displaying different dissolution properties and therefore different bioavailability. Some may even be more effective than the originally discovered substance.

This application note describes the use of a PANalytical X-ray powder diffractometer for high-throughput, high-resolution polymorph screening.

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