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Diffraction on aerosol drugs. Measurements on small quantities of pharmaceutical samples

A Theta-Theta diffractometer equipped with a solid-state detector was used to analyze the crystal structure of Ventolin™ (salbutamol) and to quantify small amounts delivered by a pressurised metered dose inhaler (pMDI). It is shown that high-quality data can be obtained without any special sample preparation method or equipment.

One of the most common pharmaceutical applications of aerosols (gas borne suspensions of liquid or solid particles) is delivery of therapeutic drugs to the lungs for the treatment of lung diseases. A typical example is Ventolin™ (salbutamol®).

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